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Wellbutrin
Wellbutrin is a drug licensed to treat depression, which is a condition usually caused by the unbalanced level of a certain brain chemical. Wellbutrin, coming in the form of pills, is able to block the reuptake of that chemical. Usually it is prescribed to be taken 2 to 4 times a day. The patient taking it might face such side effects as nausea, insomnia, and weight loss.
What Is Wellbutrin And What Is It Used for?
Wellbutrin® (bupropion hydrochloride) is used as a remedy for depression (the medical condition also known as major or clinical depression)
Who Manufactures Wellbutrin?
The brand-name version of Wellbutrin is produced by GlaxoSmithKline. Generic Wellbutrin is manufactured by several companies.
In What Way Does Wellbutrin Work?
Wellbutrin belongs to the group of norepinephrine and dopamine reuptake inhibitors (NDRI), which affect norepinephrine and dopamine, specific chemicals of the brain tissue, which participate in the process of sending signals from one nerve cell to another.
The signal is transferred by the chemical (either norepinephrine or dopamine) being released into the inter-cellar space by the cell sending it. The chemical reaches the nerve cell next to the first one, activates its receptors and thus the signal is taken and sent forward. As this is done, the "reuptake" takes place, when the first cell absorbs the chemical (norepinephrine or dopamine) remaining in the cell gap back.
When the level of the chemicals is balanced, this process causes no problems, but when any of the chemicals falls out of balance it may set up different dysfunctions, for instance, depression and seasonal affective disorder. Wellbutrin serves as a means to block the reuptake of norepinephrine and dopamine, they remain in the gap in larger quantities which gives more chances of transmitting the message properly as the receptors of the adjacent cell are activated more intensively.
Right now only NRDI antidepressants having bupropion in their content are approved to be used. Wellbutrin is the short-acting drug containing it. The long-acting forms are the following:
- Wellbutrin SR® (bupropion SR), usually taken twice a day
- Wellbutrin XL® (bupropion XL), taken once a day
- Zyban® (bupropion SR), used for smoking cessation (taken twice a day).
How Do I Take Wellbutrin?
The following are the general instructions on how Wellbutrin should be taken if prescribed:
- Wellbutrin is produced in the form of pills. If you've been prescribed Wellbutrin, you'd most probably take it two to four times a day.
- Wellbutrin might be responsible for insomnia if it is taken at bedtime. If this is the case, try taking the pill earlier in the day.
- The Wellbutrin intake is not food-dependant, but if it causes you any sort of stomach discomfort, try taking it along with meals.
- For the level of Wellbutrin in your blood to be even, take the drug at the same time each day.
- Do not violate the intake rules set up by your prescription. Overdose or taking Wellbutrin longer than is prescribed by your healthcare provider might cause serious problems.
Wellbutrin Dosage
Your healthcare provider will set up the dosage for you, and that will depend on a number of factors:
- Your age
- Whether you do or do not take any other medications
- Whether you do or do not have any other health disorders.
You are not recommended to change the dosing scheme unless you're told to do so by your healthcare provider.
Possible Side Effects of Therapy with Wellbutrin
As any other drug Wellbutrin is not free of side effects, though they do not always accompany the drug's intake. Moreover, the majority of patients undergoing the Wellbutrin therapy do not encounter any problems, and even if the side effects occur, they take minor forms and can be easily cured by the patient himself or with the help of his healthcare provider. Serious side effects are fewer and less frequently encountered. The following list shows the most common side effects of Wellbutrin:
- Agitation
- Weight loss
- Dry mouth
- Constipation
- Headaches
- Nausea or vomiting
- Dizziness
- Increased sweating
- Shakiness (tremors)
- Insomnia
- Appetite loss.
Possible Drug Interactions with Wellbutrin
Wellbutrin® (bupropion hydrochloride) in the course of the therapy might interact with a certain number of other medications and substances, which are as follows:
- Alcohol
- Other antidepressants
- Amantadine (Symmetrel®)
- Antipsychotic medications (used to treat hallucinations or schizophrenia)
- Beta blockers, such as:
- Atenolol (Tenormin®)
- Bisoprolol (Zebeta®)
- Carvedilol (Coreg®, Coreg CR®)
- Labetalol (Trandate®)
- Metoprolol (Lopressor®, Toprol XL®)
- Nadolol (Corgard®)
- Propranolol (Inderal®)
- Sotalol (Betapace®)
- Timolol (Blocadren)
- Certain arrhythmia medications, including propafenone (Rythmol®) and flecainide (Tambocor®)
- Cyclophosphamide (Cytoxan®)
- Doxorubicin (Adriamycin®, Doxil®)
- Efavirenz (Sustiva®)
- Levodopa (Parcopa®, Sinemet®, Sinemet CR®, Stalevo®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Nelfinavir (Viracept®)
- Nicotine patches (Nicoderm CQ®, Nicotrol®)
- Orphenadrine (Norflex®)
- Ritonavir (Norvir®)
- Steroids, such as prednisone or methylprednisolone (Medrol®)
- Theophylline
- Thiotepa.
What Medical Conditions Can Serve as a Contra-Indication to Using Wellbutrin?
Before taking Wellbutrin do not forget to mention to your therapist if you have any of the following medical conditions:
- Seizures or epilepsy
- A brain tumor
- A history of head trauma or brain injury
- Diabetes
- An eating disorder, such as bulimia or anorexia
- Bipolar disorder (also known as manic depression) or a family history of bipolar disorder
- Heart disease
- A recent history of heart attack
- A history of suicide attempts or suicidal thoughts
- Liver problems, including liver failure or cirrhosis
- Kidney disease, including kidney failure (renal failure)
- Any allergies, including allergies to food, dyes, or preservatives.
Also talk to your healthcare provider if you are:
- Pregnant or thinking about getting pregnant
- Breastfeeding a baby.
Do not forget to tell your healthcare provider about any other drugs you take, controlled or over-the-counter ones, including such substances as vitamins or herbal supplements.
Is There Any Alternative to Therapy with Wellbutrin?
Depression, even if it is severe, is a curable dysfunction and the earlier you start to treat it, the more effective the treatment would be, and there would be smaller chance of relapse.
Even though there exist complementary and alternative treatments for depression, the most common one is still taking special medications (antidepressants) and a verbal therapy carried out by psychologist or psychotherapist (psychotherapy). If the state of depression is severe it might also be an option that your doctor recommends you electroconvulsive therapy (ECT).
Wellbutrin has proved to be effective in treating depression; it is also well tolerated by most people. However, depending on the individual characteristics of the state treated and the patient, side effects may occur, in which case your doctor will find it necessary to recommend you an alternative drug of similar effect. Below there is a list of possible options for such substitution:
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
- Tricyclic antidepressants
- Monoamine oxidase inhibitors (MAOIs).
What Should I Do in Case of Overdose with Wellbutrin?
The overdose with Wellbutrin might have any or the combination of any of the following symptoms:
- Seizures
- Hallucinations
- Fainting
- A rapid heart rate (tachycardia)
- Irregular heart rhythms (arrhythmias)
- A fever
- Muscle tension, pain, and damage
- Low blood pressure (hypotension)
- Breathing problems
- Coma
- Loss of life.
In case you overdose, you need to call for immediate professional medical help.
How Should I Store Wellbutrin?
Wellbutrin should be stored in a proper airtight container at the room temperature away from moisture, and out of children's reach.
What Should I Do in Case I Miss a Dose of Wellbutrin?
Take your dose as soon as you remember that you've missed one, unless it is time for the next, in which case just continue according to your usual scheme. Never double a dose to make up for the one you've skipped.
Available Forms of Wellbutrin
Wellbutrin pills are available for purchase in the following strengths:
- Wellbutrin 75 mg
- Wellbutrin 100 mg.
Is Wellbutrin Available in the Form of a Generic Medication?
Right now Wellbutrin is available for purchase in the brand-name as well as in the generic forms.
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