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Tramadol is an FDA-approved drug used in the treatment of moderate to moderately severe pains. Tramadol is available in the form of tablets that are usually recommended to be taken as needed – most often once in every four to six hours (but not more frequently). The abuse potential of tramadol is very high since this drug has similar effect with morphine. Tramadol is not to be prescribed to the people with a history of alcohol or drug dependence. The list of possible side effects of tramadol includes migraines, sleepiness, nausea and/or vomiting.
What Is Tramadol and What Is it Used for?
Tramadol hydrochloride (Ultram) is a drug available by prescription and used in the treatment of moderate to moderately severe pains in adults. In some states is it still classified as controlled substance due to its high abuse potential while on the majority of the US territory it is not.
What Is the Effect of Tramadol Based on?
Tramadol belongs to the class of drugs called "centrally acting opioid analgesics", which means that it affects the nerve endings in human brain and spinal cord relieving pain similarly to morphine. Just like morphine, tramadol binds to certain opioid receptors (μ ("mu") receptors).
The effect of tramadol can also be described as similar to that of some antidepressant medications that inhibit the reuptake of certain brain chemicals, namely, serotonin and norepinephrine. These two chemicals are used to transfer the signals of pain from one nerve ending to another. The pain signal traveling through the human body stops at the end of every nerve cell causing the release of serotonin or norepinephrine. These chemicals enter the intercellular gap and activate the following nerve cell making the signal move on. Immediately after the signal is transmitted, the first cell absorbs the serotonin or norepinephrine remaining in the intercellular gap. This process of absorbing the chemicals is what is called the "reuptake."
Does Tramadol Have Any Side Effects?
Similarly to any other prescription medicine, tramadol is known to be capable of producing certain side effects among the most common of which are:
- Constipation
- Nausea and/or vomiting
- Dizziness or vertigo
- Migraines
- Sleepiness.
However, not every patient taking tramadol will experience any of the side effects listed above. Most people tolerate this medication quite well. Moreover, most of the occurring side effects are minor ones and either do not require any specific treatment or can easily be cured by the patient himself/herself. Serious side effects are very rare.
What Should I Inform My Healthcare Provider about before Starting to Take Tramadol?
Make sure to inform your healthcare provider about the following health conditions should you happen to have any:
- Seizures or epilepsy
- Liver disease (cirrhosis, liver failure, hepatitis, etc)
- Kidney disease (renal failure, etc)
- A history of head injury or high intercranial pressure
- Severe abdominal pain
- Any lung disease
- A history of alcohol or drug abuse
- Any allergies to foods, food colorings, or preservatives.
You should also inform your healthcare provider if you are:
- Pregnant or planning to become pregnant in the near future
- Breastfeeding a baby.
Always make sure that your healthcare provider knows about all other prescription and non-prescription medicines including vitamins, herbal supplements and food additives that you are taking.
Tramadol Dosage
The following list states the factors that can influence the recommended dosage of tramadol in your particular case:
- Your reaction to the effects of tramadol
- Other medications you may currently be taking
- Your age
- Other health disorders you may have.
Never try to adjust the dose of tramadol by yourself unless specifically instructed to do so by your healthcare provider.
Possible Drug Interactions with Tramadol
The list of drugs and substances that tramadol can potentially interact with goes as follows:
- Alcohol
- Carbamazepine
- Cyclobenzaprine
- Dextromethorphan (commonly used in cough suppressants)
- Digoxin
- Linezolid
- Medications that cause drowsiness, such as
- Antipsychotic medications
- Anxiety medications
- Most antidepressants
- Narcotic pain relievers
- Sleep medications
- Some antihistamines
- Promethazine
- Quinidine
- Sibutramine
- St. John's wort
- Triptans
- Tryptophan
- Warfarin.
What Should I Do in Case of Overdose with Tramadol?
Taking too much tramadol can be very dangerous. In case you suspect an overdose with this medication, seek emergency medical attention.
What Should I Do in Case I Miss a Dose of Tramadol?
Tramadol is most often used as needed, so it is not likely that you will miss a dose of it. If you forget to take Tramadol in time and feel significant pangs of pain, take the missed dose immediately. However, you should avoid using Tramadol more frequently than once in every four to six hours at all times.
Abuse Potential of Tramadol
Tramadol has the effect similar to that of morphine, which leads to its high abuse potential. Tramadol is known to cause strong psychological and physical dependence. Therefore, this medication is sold by prescription almost everywhere.
Since tramadol is a very popular drug of abuse, many people try purchasing it by illegal means – for instance, from foreign retailers or online pharmacies that don't ask for doctor's prescription.
How Do I Take Tramadol?
This section contains common suggestions concerning the use of tramadol. Please, take the time to read it carefully:
- Tramadol is available in tablet form designed for peroral administration. In most cases people are recommended to take it as needed – but not more frequently than once in every four to six hours.
- Most patients are recommended to start the therapy with a small dose of tramadol and increase it slowly over time.
- Tramadol can be taken both with and without food. However, if this med causes upset stomach in your case, it's better if you take it during a meal.
- Never drink alcohol when taking tramadol!
- Always take tramadol in full accordance with the doctor's prescription in order to ensure its maximum effectiveness. Never try to adjust the dose on your own unless specifically instructed to do so by you healthcare provider. Don't stop taking tramadol suddenly in the end of the treatment course since it may case severe withdrawal symptoms.
Is Tramadol Available in the Form of a Generic Medication?
Yes, tramadol is available in the form of a generic medication – Generic Ultram.
Who Manufactures Tramadol?
Brand-name tramadol included into Generic Ultram is manufactured by Janssen Ortho, LLC and marketed by Ortho-McNeil Pharmaceutical, Inc. There are also other generic versions of this medication manufactured by different pharmaceutical companies.
How Should I Store Tramadol?
Store tramadol tablets at room temperature, away from excess heat and moisture. Keep tramadol out of the reach of children and pets. Since tramadol is a drug of abuse, keep it in a safe place where other people cannot find it.
What Strengths Is Tramadol Available in?
There is only one strength that tramadol tablets are currently available in – tramadol 50 mg.
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