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Nolvadex
Nolvadex is a prescription medication used in the treatment of certain kinds of breast cancer. It is also prescribed as a means of prevention of metastatic breast cancer, ductal cancinoma in situ, and node-positive breast cancer in women who are likely to have any of these diseases. Nolvadex is available in the form of tablets that are usually taken on a daily basis, once or twice each day. The list of possible side effects of Nolvadex includes the following conditions: hot flashes, vaginal discharge, nausea, etc.
What Is Nolvadex And What Is It Used for?
Nolvadex (generic name: tamoxifen citrate) is a drug used for treatment and prevention of breast cancer both in men and women. This medication has been licensed for use in the following conditions:
- Treating metastatic breast cancer (form of cancer spreading in the breast tissue) both in male and female patients
- Treating node-positive breast cancer (form of breast cancer damaging the lymph nodes) in postmenopausal female patients after breast cancer surgery or radiation therapy
- Treating DCIS (ductal carcinoma in situ), an early stage of cancer damaging the ducts of the breasts but not spreading on to the main part of the breast tissue, in female patients after breast cancer surgery or radiation therapy. Often used in order to prevent invasive breast cancer
- Prevention of breast cancer in female patients who are likely to suffer from any form of breast cancer listed above.
Who Manufactures Nolvadex?
The brand name Nolvadex was first used by AstraZeneca Pharmaceuticals. However, this company no longer makes this drug. Currently, Nolvadex is manufactured by several other pharmaceutical companies.
What Is the Effect of Nolvadex Based Upon?
Nolvadex belongs to a group of drugs known under the common name of selective estrogen receptor modulators (SERMs). The medications belonging to this group are known to possess both estrogenic and anti-estrogenic effects. The peculiarity of Nolvadex is that is produces anti-estrogenic effect on the breast tissue, while its effect on bones is utterly estrogen-like (i.e. it helps to strengthen bones).
It's well-known that many forms of breast cancer are highly receptive to the effects of estrogen, which means that this hormone causes the growth of the tumor. A tumor sensitive to the impact of estrogen normally has a special kind of receptor cells on its surface. Estrogen gets absorbed by these cells, which makes the tumor grow intensively. This form of breast cancer is known as hormone receptor-positive tumor.
The active component in Nolvadex affects the estrogen receptors in the breast tissue, stopping estrogen from getting absorbed by the body of the tumor. The treatment based on this principle is called hormonal therapy.
Proven Effects of Nolvadex
There have been a number of studies carried out to learn the effects produced by Nolvadex on female patients with breast cancer. Many of them were also aimed at studying the preventive effects of this medication on women who have undergone breast cancer surgery and radiation therapy. These medical researches included female patients with hormone receptor-positive and hormone receptor-unknown types of breast cancer. The majority of women who have undergone the therapy with Nolvadex during 5-10 years survived while most of those who had refused to take this medication did not.
The researches carried out among female patients with DCIS (ductal carcinoma in situ) who have undergone breast cancer surgery and radiation therapy have proven the preventive potential of Nolvadex associated with this type of breast cancer. The results of the studies were the following: about 17 out of 1,000 female patients suffering from DCIS and not taking Nolvadex developed invasive breast cancer during 1 year following the therapy while the same showing in women taking this drug totaled only about 10 out of 1,000.
Nolvadex is also often prescribed to women in the risk group for breast cancer. According to the results of the researches, the use of Nolvadex helped to reduce this risk by as much as 44 percent in average.
How Do I Take Nolvadex?
This section of the article contains general advice on how and how often Nolvadex is normally taken.
- Nolvadex is available in the form of pills designed for peroral use. In most cases, the patients are advised to take Nolvadex once or twice a day.
- Nolvadex can be taken with or without food. However, if this drug causes upset stomach, it will be better if you take it during the course of a meal.
- It's important to maintain an even level of Nolvadex in your blood during the course of the therapy, that's why it's recommended to take it at the same time (or times) each day.
- Always take Nolvadex in full accordance with the doctor's prescription. Don't stop the therapy with this medication unless told to do so by your healthcare provider.
Nolvadex Dosage
The recommended dosage of Nolvadex is not the same for all patients. Below is the short list of factors that can affect the specified dosage for a particular patient:
- The stage of spreading of breast cancer in a particular patient
- Whether Nolvadex is being used as a means of treatment of breast cancer or as a means of preventing it
- Simultaneous therapy with other medications
- The presence or absence of other health disorders in a particular patient.
Never try to adjust your dose of Nolvadex unless told to do so by your healthcare provider.
Possible Side Effects of Therapy with Nolvadex
All prescription medications have certain side effects and Nolvadex is not an exception. However, far not all the people taking this medication are expected to suffer from any of its possible side effects. Most of the side effects experienced by patients taking this drug are minor ones, i.e. they do not require any specific treatment or can easily be treated by your therapist. The majority of people undergoing the therapy with Nolvadex are not likely to suffer from its serious side effects.
Most common possible side effects of therapy with Nolvadex are the following:
- Hot flashes
- Vaginal discharge
- Fluid retention
- Vomiting or nausea
- Irregularity of menstrual periods.
Possible Drug Interactions with Nolvadex
Below is the short list of medications that Nolvadex can possibly interact with:
- Aminoglutethimide
- Anastrozole
- Bromocriptine
- Certain anticonvulsants
- Medications used in the course of chemotherapy
- Estrogen-based drugs or other hormone replacement therapy means
- Letrozole
- Orally administered birth control pills
- Rifamycin antibiotics
- Warfarin
What Medical Conditions Can Serve as a Contra-Indication to Using Nolvadex?
Always make sure you inform your healthcare provider about any of the following conditions in case some of them apply to you before starting the therapy with Nolvadex:
- Unexplained vaginal bleeding
- Recent history of blood clot or stroke
- Allergy, including allergies to any foods, food colorings, or preservatives.
You should also warn your therapist in case you are:
- Pregnant or planning to become pregnant in the near future
- Breastfeeding a baby.
Inform your therapist about all the medicines, vitamins and food additives that you are taking (both prescription and over-the-counter ones) prior to the beginning of therapy with Nolvadex.
What Should I Do in Case of Overdose with Nolvadex?
People taking too much Nolvadex may experience the following symptoms:
- Tremor (uncontrolled trembling of the body)
- Overactive reflexes
- Coordination and walking problems
- Dizziness
- Heart arrhythmia
- Seizures.
Contact your healthcare provider immediately if you suspect an overdose with Nolvadex.
How Should I Store Nolvadex?
Store Nolvadex at room temperature away from excess moisture and heat. It's also recommended to store the pills in an airtight container.
Keep Nolvadex and all other drugs in places where children or pets can't reach them.
What Should I Do in Case I Miss a Dose of Nolvadex?
In case you miss a scheduled dose of Nolvadex, take it as soon as remembered. However, if it's almost the time for the next dose, skip the missed one and continue taking the drug in accordance with your usual schedule. Never double the dose in attempt to catch up.
Available Forms of Nolvadex
Generic Nolvadex pills are offered in the following strengths:
- Tamoxifen 10 mg
- Tamoxifen 20 mg.
Tamoxifen is also available in a liquid form under the brand-name Soltamox™. The liquid oral solution comes in one strength form only – 10 mg per 5 mL, equal to 10 mg per teaspoonful.
Is Nolvadex Available in the Form of a Generic Medication?
Brand-name Nolvadex is no longer manufactured by AstraZeneca Pharmaceuticals, so you are likely to find generic Nolvadex pills produced by a large number of different pharmaceutical companies.
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