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Aldactone
Aldactone is a drug belonging to the class of diuretics, the medications used to treat high blood pressure, water retention, low potassium levels. The drug may also be used in the process of diagnosing and treating primary hyperaldosteronism. Aldactone pills are licensed to be sold only by prescription and are usually recommended to be taken once or twice a day. It is not spared of side effects, among which one can observe diarrhea, headache, fever, and drowsiness.
What Is Aldactone And What Is It Used for?
Aldactone® (spironolactone) is a prescribed "potassium-sparing" diuretic used in the treatment of various dysfunctions, for example high blood pressure, water retention etc.
Aldactone is generally used as a remedy for the following states:
- Diagnosing and treating primary hyperaldosteronism (overproduction of the hormone aldosterone)
- Controlling high blood pressure (hypertension)
- Treating water retention (edema) caused by the following conditions:
- Congestive heart failure (CHF)
- Cirrhosis of the liver
- Kidney disease
- Treating low levels of potassium in the blood (hypokalemia).
Who Manufactures Aldactone?
The brand-name version of the drug is produced by Pfizer. Aldactone in the form of generic medication is manufactured by several different producers.
In What Way Does Aldactone Work?
All diuretics including Aldactone are sometimes also called "water pills". Aldactone is an "aldosterone antagonist", meaning it is able to block aldesterone receptors, which produce a hormone to retain water. By doing so, Aldactone provokes the increase in the level of salt and water removed from the blood though kidneys which are later released from the body with urine. When the amount of water removed from the blood is increased, the volume of the blood is decreased. As a result, the blood pressure is lowered. The drug may also be helpful with water retention.
Being a "potassium-sparing" diuretic, Aldactine, unlike some other diuretics, does not cause low potassium blood levels. On the contrary, generally it increases potassium levels, and this effect may be used in treatment of hypokalemia (the state of low potassium levels).
How Do I Take Aldactone?
Generally the advice on the intake schedule and dosage of Aldactone is the following:
- The Aldactone pills are usually taken orally one or two times a day.
- The Aldactone intake is not food dependant, so it is not necessarily that you take the pills in the course of the meal.
- The intake of Aldactone should be systematic, so in order to keep the level of the drug in your blood stable, take the pills every day at the same time. Though, sometimes there is no need to take the drug every day, especially in the cases of fluid retention.
- As Aldactone causes higher urination, it is generally advised to be taken in the morning in order to prevent waking up at night. If it is prescribed to be taken twice a day, the last dose is better to be taken before 6 p.m. unless it contradicts the recommendations of your therapist.
- Do not violate the prescription or stop taking the drug, or it will fail to produce the curing effect.
Aldactone Dosage
There are a number of factors which might influence the prescription of your healthcare provider. They are as follows:
- Other drugs taken in along with Aldactone
- Other dysfunctions the patient has
- The patient's response to the drug.
It is recommended to stick to the dosage prescribed by your healthcare provider and not adjust it without his instruction to or his permission.
Possible Side Effects of Therapy with Aldactone
Being a drug, Aldactone, can produce certain side effects. However it is not necessarily that every patient experiences them, even on the contrary, it is a drug that is usually well-tolerated and in most cases when it does produce side effects they are minor and might be cured by the patient himself or his healthcare provider. The list below names the most common side effects:
- Diarrhea, nausea, or vomiting
- Fever
- Confusion
- Headache
- Drowsiness
- Breast development in men (gynecomastia)
- Menstrual changes, including irregular or absent periods
- Impotence, also known as erectile dysfunction or ED.
Possible Drug Interactions with Aldactone
There are a number of drugs and substances that can cause unwanted effects due to the interaction with Aldactone® (spironolactone). They are the following:
- ACE inhibitors, including:
- Benazepril (Lotensin®)
- Captopril (Capoten®)
- Enalapril (Vasotec®)
- Fosinopril (Monopril®)
- Lisinopril (Prinivil®, Zestril®)
- Quinapril (Accupril®)
- Ramipril (Altace®)
- Alcohol
- Amiloride (Midamor®) or amiloride-HCTZ (Moduretic®)
- Angiotensin II receptor blockers (ARBs), such as:
- Candesartan (Atacand®)
- Eposartan (Teveten®)
- Irbesartan (Avapro®)
- Losartan (Cozaar®)
- Olmesartan (Benicar®)
- Telmisartan (Micardis®)
- Valsartan (Diovan®)
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Other blood pressure medicines
- Digoxin (Digitek®, Lanoxin®)
- Lithium (Eskalith®, Lithobid®)
- Narcotics, such as codeine, hydrocodone, morphine, and many others
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cataflam®, Voltaren®)
- Etodolac (Lodine®)
- Ibuprofen (Motrin®, Advil®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen
- Ketorolac (Toradol®)
- Meloxicam (Mobic®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Nabumetone (Relafen®)
- Oxaprozin (Daypro®)
- Potassium-containing products, such as:
- Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
- Potassium citrate (Urocit-K®, Polycitra-K®)
- Potassium gluconate
- Potassium phosphate (Neutra-Phos-K®, K-Phos®)
- Salt substitutes (used to flavor food)
- Triamterene (Dyrenium®) or triamterene-HCTZ (Dyazide®, Maxzide®).
What Medical Conditions Can Serve as a Contra-Indication to Using Aldactone?
Before taking Aldactone make sure to notify your healthcare provider if you experience any of the following health disorders:
- Liver disease, including cirrhosis
- Kidney disease or kidney failure
- Fluid or electrolyte problems
- Any allergies, including allergies to foods, dyes, or preservatives.
Also don't forget to mention to your healthcare provider if you are:
- Pregnant or planning to get pregnant in near future
- Breastfeeding a baby.
Also let your healthcare provider know what other medications you take, including those belonging to the group of controlled as well as over-the-counter ones, vitamins and herbal supplements.
What Should I Do in Case of Overdose with Aldactone?
Overdose with the medication results in:
- Drowsiness
- Confusion
- Rash
- Nausea, vomiting, or diarrhea
- Dizziness
- Electrolyte imbalance.
If you suffer an overdose, call for immediate professional medical help.
How Should I Store Aldactone?
The medication as usual should be stored in a proper airtight container at a dry place at room temperature out of children's reach.
What Should I Do in Case I Miss a Dose of Aldactone?
In case a dose of Aldactone is missed, it should be taken as soon as you remember this. If it is close to the time when you have to take the next dose, then skip the missed one and stick to your usual schedule. Never take a double dose of Aldactone trying to make up for the skipped one.
Available Forms of Aldactone
There're currently three strengths of Aldactone pills available:
- Aldactone 25 mg tablets
- Aldactone 50 mg tablets
- Aldactone 100 mg tablets.
Is Aldactone Available in the Form of a Generic Medication?
At the moment Aldactone is available both in the form of a brand-name and generic medication.
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